Plasma Estrogens and Estrogen Receptors in Breast Cancer Patients
Author Information
Author(s): R.C. Mason, W.R. Miller, R.A. Hawkins
Primary Institution: University Department of Clinical Surgery, Royal Infirmary, Edinburgh, UK
Hypothesis
What is the relationship between plasma estrogen levels and estrogen receptor concentration in breast tumors of postmenopausal women?
Conclusion
The study found a significant positive correlation between estrogen receptor levels in breast tumors and plasma oestrone concentrations in postmenopausal women.
Supporting Evidence
- 72% of the tumors were ER-positive and 28% were ER-negative.
- A significant positive correlation was found between the level of ER in the tumor and the level of oestrone in the plasma.
- The plasma levels of oestradiol-17# were much lower and showed a non-significant relationship with tumor ER activity.
Takeaway
This study looked at how estrogen levels in the blood relate to the presence of estrogen receptors in breast cancer tumors in older women.
Methodology
The study measured plasma levels of oestrone and oestradiol-17/3 and estrogen receptor activity in tumor samples from 50 postmenopausal women.
Participant Demographics
50 postmenopausal women with primary breast cancer
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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