Human angiogenin, an organogenic protein
1988
Human Angiogenin: A Protein That Helps Form Blood Vessels
publication
Evidence: moderate
Author Information
Author(s): J.F. Riordan, B.L. Vallee
Primary Institution: Harvard Medical School
Hypothesis
Can angiogenin, a protein found in human plasma, induce blood vessel formation?
Conclusion
Angiogenin is a potent inducer of blood vessel formation and has unique ribonucleolytic activity.
Supporting Evidence
- Angiogenin is found in human plasma at a concentration of 400 µg/l.
- It inhibits protein synthesis in cell-free systems.
- Angiogenin shows activity in inducing blood vessel formation on the chick chorioallantoic membrane.
Takeaway
Angiogenin is a special protein that helps create new blood vessels, which is important for growth and healing.
Methodology
Angiogenin was isolated from human plasma and tumor cell-conditioned medium, and its activity was tested on the chick chorioallantoic membrane.
Limitations
The study does not address the long-term effects of angiogenin or its behavior in living organisms.
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