Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats
2006
Role of P2X3/P2X2/3 Receptors in Pain Control
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Fukui Masato, Nakagawa Takayuki, Minami Masabumi, Satoh Masamichi, Kaneko Shuji
Primary Institution: Kyoto University
Hypothesis
Do supraspinal P2X3/P2X2/3 receptors play an inhibitory role in pain transmission?
Conclusion
The study suggests that supraspinal P2X3/P2X2/3 receptors inhibit pain transmission.
Supporting Evidence
- Intracerebroventricular administration of A-317491 reduced the antinociceptive effect of α,β-methylene-ATP.
- Repeated pretreatment with antisense oligodeoxynucleotide for P2X3 diminished the antinociceptive effect.
- A-317491 enhanced inflammatory nociceptive behaviors induced by formalin and acetic acid.
Takeaway
This study found that certain receptors in the brain help reduce pain, and blocking them can make pain worse.
Methodology
The study used intracerebroventricular injections in rats to assess the effects of specific receptor antagonists on pain responses.
Participant Demographics
Male Sprague-Dawley rats weighing 180–250 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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