Penetration of Piperacillin/Tazobactam Into Gynecologic Tissues
Author Information
Author(s): William F. O'Brien, Shelley George
Primary Institution: University of South Florida College of Medicine
Hypothesis
This study was undertaken to determine plasma and pelvic tissue concentrations of piperacillin/tazobactam following a single intravenous administration.
Conclusion
Piperacillin/tazobactam demonstrates favorable penetration in female genital tract tissues and should be considered a potentially effective agent for female pelvic infections.
Supporting Evidence
- Piperacillin/tazobactam retained an 8:1 ratio in plasma samples for up to 96 min after administration.
- Tissue concentrations showed significant penetration in endometrial, myometrial, ovarian, and fallopian tube tissues.
- The study included women in good general health scheduled for elective hysterectomy.
Takeaway
The study found that a medicine called piperacillin/tazobactam gets into the tissues of women's reproductive organs well, which could help treat infections there.
Methodology
Plasma and tissue samples were obtained following administration of 3 g of piperacillin and 0.375 g of tazobactam, and concentrations were determined by chromatography.
Limitations
Two patients were excluded from analysis due to receiving additional antibiotics or having improperly stored samples.
Participant Demographics
Women aged 18 and older, weighing between 47.7 and 95.4 kg.
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