Prostaglandin E 2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells
2000
How Arachidonic Acid Affects Prostate Cancer Cells
publication
Author Information
Author(s): Chen Y, Hughes-Fulford M
Primary Institution: University of California, San Francisco and Veterans Affairs Medical Center
Hypothesis
Arachidonic acid induces c-fos expression in human prostate cancer cells through the PGE2 and protein kinase A pathway.
Conclusion
The study found that arachidonic acid induces c-fos expression in prostate cancer cells via prostaglandin E2 and the protein kinase A pathway.
Supporting Evidence
- Arachidonic acid increases growth of prostate cancer cells.
- c-fos mRNA was induced shortly after addition of arachidonic acid.
- Prostaglandin E2 production increased significantly with arachidonic acid.
- Inhibition of cyclo-oxygenase blocked c-fos expression and PGE2 production.
Takeaway
Arachidonic acid helps prostate cancer cells grow by triggering a specific gene, and this process is influenced by certain proteins.
Methodology
The study investigated c-fos expression and PGE2 production in a human prostate cancer cell line using various inhibitors.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website