Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer
1992
Corrections on p53 Gene Abnormalities in Pancreatic Cancer
publication
Author Information
Author(s): C.M. Barton, S.L. Staddon, C.M. Hughes, P.A. Hall, C. O'Sullivan, G. Klöppel, B. Theis, R.C.G. Russell, J. Neoptolemos, R.C.N. Williamson, D.P. Lane, N.R. Lemoine
Conclusion
The CaPan-1 cell line was found to have a point mutation in the p53 gene, contrary to previous reports.
Supporting Evidence
- The previous study reported no mutation in the CaPan-1 cell line despite high p53 protein levels.
- New findings indicate a mutation at codon 159 changing Alanine to Valine.
Takeaway
Scientists found a mistake in their earlier study about a gene related to pancreatic cancer, discovering a mutation that they didn't see before.
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