Vinpocetine Osmotic Pump Tablet Study
Author Information
Author(s): Ning Meiying, Zhou Yue, Chen Guojun, Mei Xingguo
Primary Institution: National Research Institute for Family Planning
Hypothesis
Can vinpocetine be effectively delivered using an elementary osmotic pump system?
Conclusion
The study found that vinpocetine osmotic pump controlled release tablets have significant controlled release characteristics and are bioequivalent to normal tablets.
Supporting Evidence
- The release rate of vinpocetine increased with more citric acid.
- The pharmacokinetic patterns showed significant differences between immediate release and osmotic pump formulations.
- The area under the plasma concentration-time curve was equivalent for both formulations.
Takeaway
This study shows that a special tablet can help deliver a medicine called vinpocetine in a way that works better and lasts longer.
Methodology
The study involved preparing vinpocetine tablets with citric acid and testing their release in vitro and in vivo using beagle dogs.
Participant Demographics
Male beagle dogs were used for the in vivo studies.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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