Effects of Ashwagandha Leaf Extract on Glioma Cells
Author Information
Author(s): Hardeep Kataria, Navjot Shah, Sunil C. Kaul, Renu Wadhwa, Gurcharan Kaur
Primary Institution: Guru Nanak Dev University
Hypothesis
The study investigates the anti-proliferative and differentiation-inducing activities of water extract of Ashwagandha leaves in glioma cells.
Conclusion
The water extract of Ashwagandha leaves limits the proliferation and migration of glioma cells and induces differentiation.
Supporting Evidence
- The extract inhibited the proliferation of C6 glioma cells by 5–75% with an IC50 of about 1.25%.
- ASH-WEX treatment led to increased expression of differentiation markers like GFAP.
- ASH-WEX reduced the migration rate of glioma cells significantly.
Takeaway
Ashwagandha leaves can help stop brain cancer cells from growing and help them become more like normal cells.
Methodology
The study involved preparing a water extract of Ashwagandha leaves and testing its effects on various glioma cell lines using assays for cytotoxicity, proliferation, and differentiation.
Limitations
The study primarily focuses on in vitro models, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website