Mammographic Density and Breast Cancer Risk in Japanese Women
Author Information
Author(s): Nagata C, Matsubara T, Fujita H, Nagao Y, Shibuya C, Kashiki Y, Shimizu H
Primary Institution: Gifu University Graduate School of Medicine
Hypothesis
Is there a relationship between mammographic density and the risk of breast cancer in Japanese women?
Conclusion
Mammographic density is associated with the risk of breast cancer in Japanese women, similar to findings in Caucasian women.
Supporting Evidence
- Significantly increased odds ratios of breast cancer were observed for breast densities of 25–49% and 50–74% in premenopausal women.
- In postmenopausal women, odds ratios were significantly increased for breast densities of 25–50% and 50–100%.
- Total breast area was significantly associated with the risk of breast cancer independent of density percent in postmenopausal women.
Takeaway
This study found that women with denser breasts are more likely to develop breast cancer, just like in other populations.
Methodology
A case-control study comparing mammographic density in women diagnosed with breast cancer to control women without breast cancer.
Potential Biases
Potential selection bias due to differences between screening participants and the general population.
Limitations
Selection bias may have affected the results as cases and controls were not retrieved from the same population.
Participant Demographics
The study included 146 women with breast cancer and 659 control women, with a focus on premenopausal and postmenopausal women.
Statistical Information
P-Value
0.004
Confidence Interval
95% CI 0.89–10.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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