Effects of vitamin D3 supplementation on oxidative stress and antioxidant enzyme after strenuous endurance exercise in healthy young men: a double-blind, placebo-controlled trial
2024

Vitamin D3 Supplementation and Oxidative Stress in Young Men

Sample size: 26 publication 10 minutes Evidence: high

Author Information

Author(s): Yang Cheng-Tse, Weng Pei-Wei, Chien Li-Hui, Kumar Sunil, Yang Ming-Ta

Primary Institution: Taipei Medical University

Hypothesis

What are the effects of vitamin D3 supplementation on oxidative stress after strenuous endurance exercise?

Conclusion

Four weeks of vitamin D3 supplementation effectively increased serum vitamin D levels and reduced oxidative stress markers in participants after strenuous exercise.

Supporting Evidence

  • Vitamin D3 supplementation increased serum 25(OH)D concentrations significantly.
  • Markers of oxidative stress were lower in the vitamin D3 group compared to the placebo group.
  • Participants adhered to the supplementation regimen with 100% compliance.

Takeaway

Taking vitamin D3 can help protect your body from damage after hard exercise, like cycling for a long time.

Methodology

Participants were given either vitamin D3 or placebo for four weeks, followed by strenuous exercise, with blood samples taken to measure oxidative stress markers.

Potential Biases

Only male participants were included, which may limit generalizability.

Limitations

The study did not assess adverse effects like hypercalcemia and lacked fat mass data.

Participant Demographics

Healthy young Taiwanese males aged 20-40.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.5114/biolsport.2025.139087

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