Predictive Factors for Coeliac Disease in Children
Author Information
Author(s): Farrier Christian E., Wanat Marta, Harnden Anthony, Paterson Amy, Roberts Nia, Saatci Defne, Hirst Jennifer
Primary Institution: Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom
Hypothesis
What are the predictive factors for coeliac disease in children and young people?
Conclusion
The study identified 14 significant predictive factors for coeliac disease in children, including type 1 diabetes and family history.
Supporting Evidence
- Having type 1 diabetes significantly increases the odds of developing coeliac disease.
- Having a first degree relative with coeliac disease also significantly raises the risk.
- Being of white ethnicity is associated with a higher risk of coeliac disease.
Takeaway
This study looked at what things might make kids more likely to get coeliac disease, like having a family member with it or getting sick often when they were little.
Methodology
The study conducted a systematic review and meta-analysis of observational and randomized trials to identify predictive factors for coeliac disease.
Potential Biases
Potential publication and selective outcome reporting bias were noted.
Limitations
The study faced limitations due to the variability in definitions and methodologies across included studies.
Participant Demographics
The study included children and young people aged 0–25 years from various countries.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website