CAPE inhibits triple-negative breast cancer through ferroptosis induction
Author Information
Author(s): Fang Qilu, Fang Qichuan, Cheng Rui, Feng Tingting, Xin Wenxiu
Primary Institution: Hangzhou Institute of Medicine (HIM), Zhejiang Cancer Hospital, Zhejiang, Hangzhou, China
Hypothesis
This study aimed to investigate the effects and mechanisms of CAPE on triple-negative breast cancer (TNBC).
Conclusion
CAPE possesses a resistance effect on TNBC via activation of AMPK and Foxo3 signaling pathways.
Supporting Evidence
- CAPE treatment enhanced the phosphorylation of AMPK and promoted the nuclear translocation of Foxo3.
- CAPE significantly inhibited tumor growth in nude mice bearing TNBC xenografts.
- Co-incubation with Fer-1 diminished CAPE’s suppressive effects on proliferation and apoptosis induction.
- Inhibition of both AMPK and Foxo3 reversed the growth retardation induced by CAPE.
Takeaway
CAPE, a compound from propolis, helps fight a tough type of breast cancer by making cancer cells die in a special way called ferroptosis.
Methodology
MDA-MB-231 and MDA-MB-468 cells were treated with CAPE, and various assays were performed to analyze cell proliferation, apoptosis, and ferroptosis.
Limitations
CAPE faces limitations regarding its application in treatment and prevention strategies due to its low solubility and bioavailability.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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