FEZ2 Has Acquired Additional Protein Interaction Partners Relative to FEZ1: Functional and Evolutionary Implications
2011
FEZ2 Acquires New Protein Interaction Partners Compared to FEZ1
Sample size: 59
publication
Evidence: moderate
Author Information
Author(s): Alborghetti Marcos R., Furlan Ariane S., Kobarg Jörg
Primary Institution: Laboratório Nacional de Biociências, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo, Brasil
Hypothesis
FEZ2 has evolved to acquire additional protein interaction partners compared to FEZ1.
Conclusion
FEZ2 interacts with 59 proteins, of which 19 are specific to FEZ2, suggesting it has gained new functions compared to FEZ1.
Supporting Evidence
- FEZ2 interacted with 59 proteins, indicating a broad interaction network.
- Of the 40 proteins that interacted with FEZ1, 36 also interacted with UNC-76.
- FEZ2 shows a ubiquitous expression pattern, unlike FEZ1 which is restricted to the nervous system.
Takeaway
Scientists found that a protein called FEZ2 can connect with more partners than its relative FEZ1, which might mean it has new jobs in the body.
Methodology
The study used a yeast two-hybrid system to analyze protein interactions.
Digital Object Identifier (DOI)
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