MIMOX: A Web Tool for Phage Display Based Epitope Mapping
Author Information
Author(s): Huang Jian, Gutteridge Alex, Honda Wataru, Kanehisa Minoru
Primary Institution: Bioinformatics Center, Institute for Chemical Research, Kyoto University
Hypothesis
MIMOX aims to provide a convenient online tool for mapping native epitopes of antibodies using phage display technology.
Conclusion
MIMOX is a publicly available web tool that facilitates the mapping of native epitopes, complementing existing programs.
Supporting Evidence
- MIMOX can reproduce mappings from existing tools like FINDMAP and 3DEX.
- Initial case studies show MIMOX provides novel and rational results.
- MIMOX is designed to be more interactive than automatic, allowing users to find reasonable results based on their knowledge.
Takeaway
MIMOX is a free online tool that helps scientists find where antibodies attach to proteins, making it easier to study and develop new drugs.
Methodology
MIMOX uses Perl scripts to align mimotope sequences and map them onto antigen structures, allowing for interactive visualization of potential epitopes.
Limitations
The tool may require tuning of parameters for optimal results and does not guarantee identification of all epitopes.
Digital Object Identifier (DOI)
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