Synthesis and Analgesic Activity of q6-(Anisole)-Triscarbonyl-Chromium(0)
Author Information
Author(s): Marcio Lufs Andrade e Silva, Alberto Federman Neto, Joseph Miller
Primary Institution: Universidade de Franca
Hypothesis
The study investigates the analgesic activity of q6-(anisole)-triscarbonyl-chromium(0) in Wistar rats.
Conclusion
The compound q6-(anisole)-triscarbonyl-chromium(0) exhibits significant analgesic activity, higher than dipyrone but lower than morphine.
Supporting Evidence
- Two doses of the compound were tested: 30 mg/Kg and 50 mg/Kg.
- The analgesic activity was evaluated using the Hot Plate Test method.
- The compound showed a significant analgesic effect compared to the control group.
- The analgesic effect was not as high as that of morphine.
Takeaway
Scientists made a new compound and tested it on rats to see if it could help with pain. It worked better than some common pain relievers.
Methodology
The compound was synthesized and its analgesic activity was evaluated using the Hot Plate Test on Wistar rats.
Limitations
The study did not explore the toxicology and side effects of the compound.
Participant Demographics
Male Wistar rats weighing approximately 170g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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