D-Serine May Help Improve Brain Function in Mice with Anti-NMDAR Encephalitis
Author Information
Author(s): Luo Hanyu, Yang Xiaoyue, Yang Jiaxin, Han Ziyao, Huang Dishu, Gui Jianxiong, Ding Ran, Chen Hengsheng, Cheng Li, Ma Jiannan, Jiang Li, Meloni Bruno, Gu Zhenglin
Primary Institution: Department of Neurology, Children’s Hospital of Chongqing Medical University
Hypothesis
Can D-serine supplementation mitigate synaptic plasticity impairments caused by anti-NMDAR antibodies in a mouse model?
Conclusion
D-serine treatment can improve hippocampal plasticity impairments caused by anti-NMDAR antibodies but does not reverse the decreased expression of NMDAR.
Supporting Evidence
- Mice injected with anti-NMDAR antibodies showed reduced hippocampal long-term potentiation compared to controls.
- D-serine treatment significantly improved long-term potentiation in mice with anti-NMDAR antibodies.
- Behavioral tests showed no significant differences between treated and control groups.
Takeaway
This study found that giving D-serine to mice with a specific brain condition helped their brains work better, but it didn't fix all the problems.
Methodology
Mice were injected with anti-NMDAR antibodies and treated with D-serine or saline, followed by various behavioral and electrophysiological tests.
Limitations
A single injection of anti-NMDAR antibodies did not induce behavioral changes associated with the condition in mice.
Participant Demographics
Three patients diagnosed with anti-NMDAR encephalitis provided cerebrospinal fluid samples.
Statistical Information
P-Value
0.0194
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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