Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8
1999
Ribozymes Induce Cell Death in Myeloid Leukaemia
publication
Evidence: moderate
Author Information
Author(s): Matsushita H, Kizaki M, Kobayashi H, Muto A, Ikeda Y
Primary Institution: Keio University School of Medicine
Hypothesis
Can ribozymes targeted against AML1/MTG8 induce apoptosis in myeloid leukaemic cells?
Conclusion
Ribozymes targeting AML1/MTG8 can induce apoptosis in myeloid leukaemic cells with the t(8;21) translocation.
Supporting Evidence
- Ribozymes specifically inhibited the growth of Kasumi-1 cells with the t(8;21) translocation.
- Morphological changes indicative of apoptosis were observed in treated Kasumi-1 cells.
- DNA ladder formation suggested that ribozymes induced apoptosis in Kasumi-1 cells.
Takeaway
Scientists found that special molecules called ribozymes can help kill certain cancer cells by making them die instead of grow.
Methodology
The study involved incubating myeloid leukaemia cells with ribozymes and observing their effects on cell growth and apoptosis.
Digital Object Identifier (DOI)
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