Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells
2011
Different roles of STAT3 in gastric cancer
publication
Evidence: moderate
Author Information
Author(s): Okamoto W, Okamoto I, Arao T, Yanagihara K, Nishio K, Nakagawa K
Primary Institution: Kinki University Faculty of Medicine
Hypothesis
Does the mechanism of STAT3 activation affect its role in gastric cancer cells?
Conclusion
Activated STAT3 contributes to either cell survival or motility in gastric cancer cells, depending on the mechanism of its activation.
Supporting Evidence
- STAT3 activation is linked to MET signaling in gastric cancer cells.
- Depletion of STAT3 inhibited migration and invasion of gastric cancer cells.
- IL-6 activates STAT3 through the JAK pathway in gastric cancer cells without MET activation.
- Forced expression of active STAT3 inhibited apoptosis induced by MET-TKI.
Takeaway
This study found that STAT3 can help cancer cells survive or move around, depending on how it gets activated.
Methodology
The study investigated the mechanisms of STAT3 activation and its functions in gastric cancer cells using various assays including immunoblot analysis and cell migration assays.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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