Expression and Functional Roles of Angiopoietin-2 in Skeletal Muscles
2011
The Role of Angiopoietin-2 in Skeletal Muscle Cells
publication
Evidence: moderate
Author Information
Author(s): Mofarrahi Mahroo, Hussain Sabah N. A.
Primary Institution: McGill University Health Centre
Hypothesis
Skeletal muscle cells constitutively express ANGPT2 and its production is significantly induced by pro-inflammatory cytokines and reactive oxygen species.
Conclusion
ANGPT2 promotes skeletal myoblast survival and differentiation, suggesting it plays a positive role in muscle fiber repair.
Supporting Evidence
- ANGPT2 is constitutively expressed in human and murine primary skeletal myoblasts.
- ANGPT2 expression increases significantly during myoblast differentiation into myotubes.
- ANGPT2 expression in skeletal myoblasts is induced by H2O2 but not by TNFα, IL6, and IL1β.
- ANGPT2 triggers significant increases in survival and differentiation of skeletal myoblasts.
Takeaway
This study found that a protein called ANGPT2 helps muscle cells survive and grow, especially when they are under stress.
Methodology
Primary skeletal myoblasts were isolated from human and mouse muscles, and their responses to ANGPT2 were measured in vitro.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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