Origins of Stochasticity and Burstiness in High-Dimensional Biochemical Networks
2009
Understanding Burstiness in Biochemical Networks
publication
Evidence: moderate
Author Information
Author(s): Simon Rosenfeld
Primary Institution: Division of Cancer Prevention, National Cancer Institute
Hypothesis
The study proposes a novel scenario of burstiness in high-dimensional biochemical networks.
Conclusion
Burstiness is a fundamental property of high-dimensional nonlinear systems, arising from their inherent dynamics.
Supporting Evidence
- Burstiness is linked to heavy-tailed probability distributions in biochemical processes.
- The study outlines how deterministic behavior can lead to stochastic-like noise in biochemical networks.
- Stochastic cooperativity is a key mechanism in understanding the dynamics of gene expression.
Takeaway
This study explains that in complex biological systems, changes can happen suddenly and unpredictably, like bursts of energy, due to the way these systems are built.
Methodology
The study uses mathematical modeling to explore the dynamics of biochemical networks and their stochastic behaviors.
Limitations
The study does not provide experimental validation for the proposed models.
Digital Object Identifier (DOI)
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