Identifying Genes Linked to Angiogenesis
Author Information
Author(s): Rivera Corban G., Mellberg Sofie, Claesson-Welsh Lena, Bader Joel S., Popel Aleksander S.
Primary Institution: Johns Hopkins University
Hypothesis
We aimed to identify novel and missing angiogenesis annotations and verify their significance to angiogenesis.
Conclusion
The study identified 293 angiogenesis-related proteins and showed differential regulation of key proteins involved in angiogenesis across endothelial cell lines.
Supporting Evidence
- The study identified 202 angiogenesis-associated proteins through a graph diffusion approach.
- Statistical analysis showed that newly associated proteins frequently had perturbed gene expression during angiogenesis.
- The analysis revealed differential regulation of HIF-1α and HIF-2α across endothelial cell lines.
Takeaway
The researchers found new proteins that help blood vessels grow, which could help in treating diseases like cancer and Alzheimer's.
Methodology
The study integrated the human interactome with known angiogenesis-annotated proteins and analyzed gene expression data from three endothelial cell lines.
Potential Biases
The selection of angiogenesis-annotated proteins may introduce inherent bias.
Limitations
The study may be biased towards highly connected proteins due to the nature of the graph diffusion method.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website