How Age Affects Bitter Taste Sensitivity
Author Information
Author(s): Mennella Julie A, Pepino M Yanina, Duke Fujiko F, Reed Danielle R
Primary Institution: Monell Chemical Senses Center
Hypothesis
Does age modify the genotype-phenotype relationship for the bitter receptor TAS2R38?
Conclusion
The study found that children with the AVI/PAV haplotype are more sensitive to bitter tastes than adults with the same genotype.
Supporting Evidence
- Children with the AVI/PAV haplotype perceived bitterness at lower concentrations than adults.
- Age was a significant modifier of the genotype-phenotype relationship for heterozygous subjects.
- No significant differences in PROP thresholds were found among homozygous haplotypes across age groups.
Takeaway
Kids can taste bitterness better than adults, especially if they have a specific gene combination.
Methodology
Participants were tested for bitter taste thresholds using a forced-choice method and genotyped for TAS2R38 alleles.
Potential Biases
Potential bias in self-reported race/ethnicity and the influence of maternal reporting.
Limitations
The study focused on specific age groups and may not represent all populations.
Participant Demographics
Participants included 448 children (3-10 years), 100 adolescents (11-19 years), and 432 adults (20-55 years), with a diverse racial/ethnic background.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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