Alcohol Consumption and Genetic Factors Affecting Cholesterol Levels in Japanese Men
Author Information
Author(s): Kawamoto Teruyoshi, Kokaze Akatsuki, Ishikawa Mamoru, Matsunaga Naomi, Karita Kanae, Yoshida Masao, Shimada Naoki, Ohtsu Tadahiro, Shirasawa Takako, Ochiai Hirotaka, Ito Taku, Hoshino Hiromi, Takashima Yutaka
Primary Institution: Showa University School of Medicine
Hypothesis
Does the Mt5178 C/A polymorphism modulate the effects of alcohol consumption on the risk of dyslipidemia in middle-aged Japanese men?
Conclusion
For men with the Mt5178C genotype, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia.
Supporting Evidence
- Alcohol consumption was significantly and negatively associated with the risk of hyper-LDL cholesterolemia in Mt5178C genotypic men.
- Daily drinkers with Mt5178C had a significantly lower odds ratio for hyper-LDL cholesterolemia compared to non-drinkers.
- No significant association was found between alcohol consumption and hyper-LDL cholesterolemia in Mt5178A genotypic men.
Takeaway
Drinking alcohol might help some men lower their bad cholesterol, but it can also cause other health problems.
Methodology
A cross-sectional study assessing the combined effect of Mt5178 polymorphism and alcohol consumption on the risk of dyslipidemia.
Potential Biases
Potential selection bias due to recruiting subjects from a hospital population.
Limitations
The study had a limited sample size and was cross-sectional, which cannot establish causality.
Participant Demographics
394 male subjects, average age 53.9 years, all Japanese.
Statistical Information
P-Value
0.015
Confidence Interval
0.153-0.847
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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