U-shaped relationship between serum uric acid and gastric cancer risk
Author Information
Author(s): Huang Junjun, Mi Ningning, Yang Jingli, Zheng Ya, Yuan Jinqiu, Meng Wenbo
Primary Institution: The First Hospital of Lanzhou University
Hypothesis
What is the relationship between serum uric acid levels and the risk of upper gastrointestinal cancer?
Conclusion
Both low and high serum uric acid levels were associated with increased risk of gastric cancer, supporting a U-shaped association.
Supporting Evidence
- SUA levels were positively associated with the risk of oral cancer in females.
- SUA levels were negatively associated with the risk of esophageal cancer in the general population.
- The risk of gastric cancer in males showed a U-shaped trend with SUA levels.
- Interaction analysis indicated that age, sex, smoking and drinking status, family history of cancer, and BMI might influence the relationship between SUA and cancer.
Takeaway
This study found that having too little or too much uric acid in your blood can increase the risk of certain stomach cancers.
Methodology
A prospective cohort study using data from the UK Biobank with participants grouped into quartiles based on serum uric acid levels.
Potential Biases
Potential biases due to the observational nature of the study and the demographic homogeneity of the sample.
Limitations
The study is observational and cannot establish causation; participants were mainly white Europeans, limiting generalizability.
Participant Demographics
The study included 436,964 participants, with 231,595 males and 235,369 females, aged 40-69 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 0.51(0.32,0.81)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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