MMP-13 and Breast Cancer Prognosis
Author Information
Author(s): Zhang Bin, Cao Xuchen, Liu Yanxue, Cao Wenfeng, Zhang Fei, Zhang Shiwu, Li Hongtao, Ning Liansheng, Fu Li, Niu Yun, Niu Ruifang, Sun Baocun, Hao Xishan
Primary Institution: Tianjin Medical University Cancer Institute and Hospital
Hypothesis
This study aims to assess the expression profile of MMP-13 protein in invasive breast carcinomas to determine its diagnostic and prognostic significance.
Conclusion
MMP-13 may serve as an independent prognostic factor for invasive breast cancer patients, particularly when evaluated alongside Her-2/neu and lymph node status.
Supporting Evidence
- MMP-13 expression by tumor cells and stromal fibroblasts correlated with carcinoma infiltration of lymph nodes.
- High levels of MMP-13 expression were associated with decreased overall survival.
- MMP-13 correlated with the expression of Her-2/neu and TIMP-1 in tumor cells.
Takeaway
MMP-13 is a protein that can help doctors understand how aggressive a breast cancer is and how likely it is to spread.
Methodology
Immunohistochemistry was performed on tissue microarrays containing specimens from 263 breast carcinomas, and the correlation of gene expression profiles with clinicopathological features and clinical outcomes was analyzed.
Potential Biases
Potential bias may arise from the retrospective nature of the study and the reliance on immunohistochemical scoring.
Limitations
The study does not address the potential influence of other unmeasured confounding factors on the outcomes.
Participant Demographics
The cohort included 263 cases of invasive breast cancer, with a median age of 50.3 years, comprising 132 premenopausal and 131 postmenopausal women.
Statistical Information
P-Value
p < 0.001 for MMP-13 expression correlation with lymph node infiltration
Confidence Interval
95% CI for overall survival was reported as 107 (98~116) months for high MMP-13 expression in tumor cells.
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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