Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin
2002
Datura stramonium agglutinin and glioma cell differentiation
publication
Evidence: moderate
Author Information
Author(s): Sasaki T, Yamazaki K, Yamori T, Endo T
Primary Institution: Tokyo Metropolitan Institute of Gerontology
Hypothesis
Can Datura stramonium agglutinin induce differentiation and inhibit proliferation of glioma cells?
Conclusion
Datura stramonium agglutinin induces differentiation and inhibits the proliferation of glioma cells.
Supporting Evidence
- DSA caused glioma cells to develop long processes and increased GFAP levels.
- Proliferation of glioma cells was significantly reduced after treatment with DSA.
- DSA's effects on cell proliferation were irreversible after a short exposure.
Takeaway
A plant extract called Datura stramonium can help brain cancer cells change into a less harmful form and stop them from growing.
Methodology
The study involved treating glioma cells with Datura stramonium agglutinin and observing changes in proliferation and morphology.
Digital Object Identifier (DOI)
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