Enhancement of a modified Mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial
2008

Improving Heart Health with a Special Diet and Supplements

Sample size: 49 publication 10 minutes Evidence: moderate

Author Information

Author(s): Robert H. Lerman, Deanna M. Minich, Gary Darland, Joseph J. Lamb, Barbara Schiltz, John G. Babish, Jeffrey S. Bland, Matthew L. Tripp

Primary Institution: Functional Medicine Research Center, MetaProteomics, LLC

Hypothesis

Can enhancing a modified Mediterranean-style diet with specific phytochemicals improve cardiometabolic risk factors in individuals with metabolic syndrome and high cholesterol?

Conclusion

The study found that adding specific phytochemicals to a modified Mediterranean diet significantly improved heart health markers in participants.

Supporting Evidence

  • Participants in the phytochemical group had greater reductions in cholesterol and triglycerides compared to the diet-only group.
  • 43% of participants in the phytochemical group resolved their metabolic syndrome compared to 22% in the diet-only group.
  • The Framingham 10-year CVD risk score decreased more significantly in the phytochemical group than in the diet-only group.

Takeaway

Eating a special diet with added plant nutrients can help people with heart health problems feel better and healthier.

Methodology

The study was a randomized, 12-week trial with 49 participants divided into two groups, one following a modified Mediterranean diet and the other receiving additional phytochemical supplements.

Potential Biases

Potential bias due to funding from a company that produces the supplements used in the study.

Limitations

The study had a small sample size and was limited to a specific age range and health condition.

Participant Demographics

Participants were aged 25-80, with a majority being women and 82% classified as obese.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1743-7075-5-29

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