In Vitro Anti-oxidant Effect of Vitamin E on Oxidative Stress Induced due to Pesticides in Rat Erythrocytes
2011
Vitamin E's Role in Reducing Pesticide-Induced Oxidative Stress in Rats
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Saxena Ronika, Garg Poonam, Jain D. K.
Primary Institution: Bareilly College, Bareilly, Uttar Pradesh, India
Hypothesis
Does vitamin E mitigate oxidative stress caused by pesticides in rat erythrocytes?
Conclusion
Vitamin E effectively reduces oxidative stress caused by endosulfan and chlorpyrifos in rat erythrocytes.
Supporting Evidence
- Endosulfan was found to be more toxic than chlorpyrifos.
- Vitamin E treatment significantly reduced lipid peroxidation levels in pesticide-exposed rats.
- Superoxide dismutase activity was lower in pesticide-exposed groups but improved with vitamin E treatment.
- Catalase activity decreased in pesticide-exposed rats but was maintained with vitamin E.
- Glutathione-S-transferase activity was higher in pesticide-exposed groups compared to vitamin E treated groups.
Takeaway
This study shows that vitamin E can help protect rats from harmful effects of certain pesticides by reducing stress in their blood cells.
Methodology
Rats were exposed to pesticides and treated with vitamin E, followed by biochemical analysis of their blood cells.
Participant Demographics
Ten male healthy rats weighing about 100–200 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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