Trends in Metabolic Syndrome Over Time
Author Information
Author(s): Kraja Aldi T, Borecki Ingrid B, North Kari, Tang Weihong, Myers Richard H, Hopkins Paul N, Arnett Donna, Corbett Jonathan, Adelman Avril, Province Michael A
Primary Institution: Washington University School of Medicine
Hypothesis
How does the prevalence of metabolic syndrome change over time and with age?
Conclusion
The prevalence of metabolic syndrome increased significantly over a 7.4-year period, particularly among older adults.
Supporting Evidence
- MetS prevalence increased from 17.1% to 28.8% over the study period.
- The odds of having prevalent coronary heart disease were about 2.5 times higher in subjects with MetS.
- The greatest increase in risk factors was observed in waist circumference, which increased by 25%.
Takeaway
This study shows that more people are developing metabolic syndrome as they get older, which is linked to being overweight and having high blood pressure.
Methodology
Participants were examined at two time points, and logistic regression was used to analyze the association of metabolic syndrome with coronary heart disease and type 2 diabetes.
Potential Biases
The recruitment design may have biased the sample towards individuals with a familial history of coronary heart disease.
Limitations
The study did not account for mortality due to coronary heart disease and had potential bias in participant recruitment.
Participant Demographics
Participants were from 480 families, with a mean age of 50.6 years at the first examination.
Statistical Information
Confidence Interval
2.1–3.8
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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