Effects of Albumin on Blood Volume in Cirrhotic Patients
Author Information
Author(s): Andreas Umgelter, Katrin Wagner, Wolfgang Reindl, Nils Nurtsch, Wolfgang Huber, Roland M Schmid
Primary Institution: Technische Universität München
Hypothesis
This study investigates the effects of plasma expansion with hyperoncotic albumin solution and the role of static haemodynamic parameters in predicting volume responsiveness in patients with advanced cirrhosis.
Conclusion
Plasma expansion with albumin significantly increases central blood volume in many patients with advanced cirrhosis.
Supporting Evidence
- After albumin infusion, central blood volume increased significantly.
- Changes in global end-diastolic volume index correlated with changes in cardiac index.
- Baseline systemic vascular resistance index was predictive of fluid responsiveness.
Takeaway
Giving albumin to patients with liver problems helps their blood volume and can make their heart work better.
Methodology
Patients with advanced cirrhosis received two infusions of 200 ml of 20% albumin, and various haemodynamic parameters were measured before and after the infusions.
Limitations
The study had an uncontrolled design and used albumin instead of crystalloid solutions for volume challenges.
Participant Demographics
50 patients (33 men, 17 women; average age 56 years) with advanced cirrhosis (Child B and C).
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1 – 3
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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