Vessel-Wall Contrast Enhancement and Stroke Risk in Moyamoya Disease
Author Information
Author(s): Haas Patrick, Hauser Till-Karsten, Wiggenhauser Lucas Moritz, Zerweck Leonie, Tatagiba Marcos, Khan Nadia, Roder Constantin
Primary Institution: University of Tübingen
Hypothesis
Is there an association between preoperative vessel-wall contrast enhancement and the occurrence of perioperative acute ischemic stroke in Moyamoya disease patients undergoing revascularization?
Conclusion
Preoperative vessel-wall contrast enhancement may indicate a higher risk of postoperative stroke in Moyamoya disease patients.
Supporting Evidence
- 67.3% of patients showed preoperative vessel-wall contrast enhancement.
- PAIS occurred in 2.1% of revascularizations.
- All patients with PAIS had preoperative pathological vessel-wall contrast enhancement.
Takeaway
Doctors found that if a patient's blood vessels show certain changes before surgery, they might be at a higher risk of having a stroke after the operation.
Methodology
This retrospective cohort study analyzed untreated Moyamoya disease patients who underwent revascularization and had preoperative MRI with vessel-wall contrast enhancement sequences.
Potential Biases
The retrospective nature of the study may lead to selection bias and confounding factors not accounted for.
Limitations
The study is retrospective, which may introduce bias, and the sample size is relatively small for the analysis of rare events like perioperative strokes.
Participant Demographics
The cohort included 110 patients with a female-to-male ratio of 2.7:1 and a median age of 45.1 years.
Statistical Information
P-Value
0.0273
Confidence Interval
1.0–1.4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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