Different Mouse Strains Show Varying Responses to Japanese Encephalitis Virus
Author Information
Author(s): Wang Kai, Deubel Vincent
Primary Institution: Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institute for Biological Sciences, Shanghai, China
Hypothesis
Differences in susceptibility to Japanese encephalitis virus (JEV) infection in mice are related to their immune responses and viral replication.
Conclusion
Mice with different susceptibilities to JEV neuroinvasion did not show changes in viral tropism and host innate immune responses prior to viral entry into the central nervous system.
Supporting Evidence
- 95% of C3H/HeN mice died by day 17 post-infection.
- 40% of DBA/2 mice died by day 21 post-infection.
- DBA/2 mice showed earlier and higher titers of neutralizing antibodies compared to C3H/HeN mice.
Takeaway
Some mice get really sick from a virus called Japanese encephalitis, while others don't. This study looked at why that happens.
Methodology
C3H/HeN and DBA/2 mice were infected with JEV and observed for mortality and immune responses.
Potential Biases
Potential bias in selecting symptomatic mice for analysis.
Limitations
The study primarily focused on two mouse strains, which may not represent all genetic variations in susceptibility to JEV.
Participant Demographics
Six-week-old female C3H/HeN and DBA/2 mice.
Statistical Information
P-Value
0.0013
Statistical Significance
p=0.0013
Digital Object Identifier (DOI)
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