Cathepsin D Levels in Ovarian Cancer
Author Information
Author(s): G. Scambia, P. Benedetti, G. Ferrandina, F. Battaglia, G. Baiocchi, S. Mancuso
Primary Institution: Catholic University, Rome, Italy
Hypothesis
Does Cathepsin D concentration correlate with pathological features and hormone receptors in ovarian cancer?
Conclusion
Ovarian tumors produce higher levels of Cathepsin D compared to normal tissues, suggesting it may be a potential prognostic marker.
Supporting Evidence
- Cath-D levels were significantly higher in malignant tumors than in normal and benign tissues.
- In six out of seven cases, metastatic deposits had higher Cath-D concentrations than primary tumors.
- 66% of cases had Cath-D levels above 12 pmoles mg-1 protein.
Takeaway
This study found that ovarian cancer tissues have more Cathepsin D than normal tissues, which might help doctors understand how aggressive the cancer is.
Methodology
Cathepsin D levels were measured in ovarian tissue samples using an immunoradiometric assay.
Limitations
The study did not find a correlation between Cathepsin D levels and various pathological parameters.
Participant Demographics
Patients aged 29 to 71 years, median age 53.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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