Safety of PolyGlycopleX® (PGX®) in Rats
Author Information
Author(s): Ray A Matulka, Michael R Lyon, Simon Wood, Ann Marone Palma, Daniel J Merkel, George A Burdock
Primary Institution: Burdock Group
Hypothesis
Is PolyGlycopleX® (PGX®) safe for consumption in rats over a 90-day period?
Conclusion
PGX is safe for rats at a dietary level of 5.0%, with no observed adverse effects.
Supporting Evidence
- Mean body weight and food consumption were comparable to control rats.
- No significant changes in neuromotor behavior were observed.
- Histopathological analysis showed no adverse effects.
- Decreased red blood cell count was noted in high dose males but was not considered adverse.
- Female rats showed increased enzyme levels but no histopathological changes.
Takeaway
Researchers fed rats a special fiber called PGX for 90 days and found it didn't harm them, even at high amounts.
Methodology
Rats were fed diets with varying levels of PGX for 90 days and evaluated for health effects.
Potential Biases
Potential bias due to financial relationships with the sponsor.
Limitations
The study was limited to a specific strain of rats and a short duration.
Participant Demographics
Sprague Dawley® rats, 7-8 weeks old, 10 males and 10 females per group.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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