Increased doxorubicin uptake and toxicity in multicellular tumour spheroids treated with DC electrical fields
1999
Increased Doxorubicin Uptake in Tumors with Electrical Fields
publication
Evidence: moderate
Author Information
Author(s): Sauer H, Pütz V, Fischer K, Hescheler J, Wartenberg M
Primary Institution: University of Cologne
Hypothesis
Can electrical fields increase the uptake and toxicity of doxorubicin in multicellular tumor spheroids?
Conclusion
Applying electrical fields to tumor spheroids increases doxorubicin uptake and toxicity due to lipid peroxidation.
Supporting Evidence
- Electrical fields increased doxorubicin uptake in treated spheroids.
- Reactive oxygen species were raised after electrical field exposure.
- Lipid peroxidation was detected following electrical field treatment.
- Lipid diffusion coefficient decreased in treated samples.
Takeaway
Using electricity on tumor cells can help them absorb more medicine, making the treatment stronger.
Methodology
Multicellular prostate tumor spheroids were treated with direct current electrical fields, and doxorubicin uptake and toxicity were measured.
Digital Object Identifier (DOI)
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