Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study
2000
Nephrotoxicity Risks in Children Treated with Ifosfamide
Sample size: 148
publication
Evidence: moderate
Author Information
Author(s): Skinner R, Cotterill S J, Stevens M C G
Primary Institution: Sir James Spence Institute of Child Health, Royal Victoria Infirmary
Hypothesis
What are the risk factors for nephrotoxicity after ifosfamide treatment in children?
Conclusion
Higher doses of ifosfamide are linked to increased nephrotoxicity in children.
Supporting Evidence
- 61 out of 123 evaluable patients had a GFR less than 90 ml/min/1.73 m2.
- 50% of fully evaluable patients experienced mild nephrotoxicity.
- Higher total ifosfamide doses correlated with greater glomerular and tubular toxicity.
Takeaway
This study looked at how ifosfamide affects kids' kidneys and found that higher doses can cause more kidney problems.
Methodology
The study evaluated renal function in children treated with ifosfamide, measuring various kidney function indicators.
Participant Demographics
Children and young people with sarcomas.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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