Factors Associated with Disease Evolution in Greek Patients with Inflammatory Bowel Disease
Author Information
Author(s): Chatzicostas Constantinos, Roussomoustakaki Maria, Potamianos Spiros, Paspatis Gregorios, Mouzas Ioannis, Romanos John, Mavrogeni Helen, Kouroumalis Elias
Primary Institution: Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
Hypothesis
What factors influence disease evolution in Crohn's disease and ulcerative colitis patients?
Conclusion
Smoking and non-colonic disease are risk factors for behavioral change in Crohn's disease patients, while proximal extension is more common in ulcerative colitis patients with proctitis than in those with left-sided colitis.
Supporting Evidence
- B1 phenotype accounted for 68.9% of Crohn's disease patients at diagnosis.
- The cumulative probability of change in disease behavior in B1 patients was 43.6% at 10 years after diagnosis.
- Active smoking and non-colonic disease were associated with behavioral change in B1 patients.
- Proctitis and left-sided colitis accounted for 24.2% and 48.4% of ulcerative colitis patients at diagnosis.
- The 10-year cumulative probability of proximal disease extension in patients with proctitis was 36.8%.
Takeaway
This study looked at how certain factors, like smoking, can change the way diseases like Crohn's and ulcerative colitis behave over time.
Methodology
116 Crohn's disease and 256 ulcerative colitis patients were followed-up for at least 5 years after diagnosis, with data analyzed actuarially.
Potential Biases
Patients with benign clinical courses may be under-represented due to the study's referral center nature.
Limitations
The study may not represent all cases of IBD in Greece due to the specific geographical area and referral centers.
Participant Demographics
Patients were from Crete, Greece, with a mix of Crohn's disease and ulcerative colitis.
Statistical Information
P-Value
0.003
Confidence Interval
95% CI: 1.40–6.45
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website