The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
2024
Deltamethrin Insecticide Affects Gut Signaling
publication
Author Information
Author(s): White Alexandria C., Krout Ian N., Mouhi Sabra, Chang Jianjun, Kelly Sean D., Caudle W. Michael, Sampson Timothy R.
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
Deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract.
Conclusion
Deltamethrin alters signaling pathways in gut cells and affects intestinal motility.
Supporting Evidence
- Deltamethrin impacts the expression of serotonergic pathways in EECs.
- Deltamethrin inhibits the release of the EEC hormone GLP-1.
- In a mouse model, deltamethrin caused a transient loss of intestinal motility.
- This constipation was linked to decreased peripheral serotonin production.
- Deltamethrin's effects on EECs may relate to diseases like inflammatory bowel disease.
Takeaway
Deltamethrin, a common insecticide, can mess with how our gut cells communicate and can make it harder for our intestines to move food.
Methodology
The study used the STC-1 EEC cell line and a mouse model to evaluate the effects of deltamethrin.
Digital Object Identifier (DOI)
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