Protective Effects of Selenium and Vitamin E Against Azithromycin-Induced Heart Damage
Author Information
Author(s): Heba Hussein Rohym, Hemeda Mohamed S., Elsayed Almoatazbellah Mahmoud, Farrag Mayada Saad, Elsayed Heba A., Ezzat Amgad A., Ibrahim Mohamed A., Makloph Mohammed
Primary Institution: Fayoum University, Egypt
Hypothesis
Can selenium and vitamin E protect against cardiac damage caused by azithromycin?
Conclusion
Selenium and vitamin E provide a protective effect against azithromycin-induced cardiac toxicity.
Supporting Evidence
- Azithromycin administration in male albino rats results in significant cardiac damage, including myocardial fibrosis, inflammation, and elevated Interleukin-10 levels.
- Selenium and Vitamin E co-administration effectively reduces Azithromycin-induced cardiotoxicity by restoring antioxidant enzyme levels and reducing oxidative stress markers.
- Histological analysis revealed that Selenium and Vitamin E mitigate myofiber disorganization and inflammatory infiltration in cardiac tissues treated with Azithromycin.
- Immunohistochemical findings showed decreased levels of caspase 3 and TNF-α in the group receiving Selenium and Vitamin E, suggesting reduced apoptosis and inflammation.
- These findings support the potential of antioxidant therapy as a protective strategy against the cardiotoxic effects of Azithromycin.
Takeaway
This study found that azithromycin can harm the heart, but giving selenium and vitamin E together can help protect it.
Methodology
Forty male albino rats were divided into four groups to assess the effects of azithromycin and the protective role of selenium and vitamin E.
Potential Biases
Potential bias in group allocation and data collection was minimized through randomization and blinding.
Limitations
The study did not assess the individual effects of selenium and vitamin E, used a rat model which may not fully represent human physiology, and had a short observation period.
Participant Demographics
Forty adult male albino rats weighing between 180 and 220 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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