Mycobacterium bovis shedding patterns from experimentally infected calves and the effect of concurrent infection with bovine viral diarrhoea virus
2006

Shedding Patterns of Mycobacterium bovis in Calves Infected with BVDV

Sample size: 12 publication Evidence: moderate

Author Information

Author(s): Kao R.R, Gravenor M.B, Charleston B, Hope J.C, Martin M, Howard C.J

Primary Institution: Department of Zoology, University of Oxford

Hypothesis

Does concurrent infection with BVDV affect the shedding patterns of Mycobacterium bovis in calves?

Conclusion

There is no statistically significant difference in the shedding patterns of calves infected with Mycobacterium bovis alone compared to those co-infected with BVDV.

Supporting Evidence

  • Calves were divided into two groups: one infected with Mycobacterium bovis alone and the other co-infected with BVDV.
  • Shedding patterns were analyzed using statistical models to account for variability.
  • No significant increase in mean CFU shedding was found in the BVDV-infected group.

Takeaway

The study looked at how sick calves release bacteria into the air and found that being sick with two germs at once doesn't change how much bacteria they release.

Methodology

The study involved 12 calves, half infected with Mycobacterium bovis alone and half co-infected with BVDV, with bacterial shedding measured over time.

Limitations

The power for detecting a significant BVDV effect was low due to high variability in CFU shedding.

Participant Demographics

Friesian cross calves from a farm free of BTB for over 10 years.

Statistical Information

P-Value

0.72

Confidence Interval

(-0.63, 12.2)

Statistical Significance

p=0.72

Digital Object Identifier (DOI)

10.1098/rsif.2006.0190

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