Tollip Is a Mediator of Protein Sumoylation
2009
Tollip and Its Role in Protein Sumoylation
publication
Evidence: moderate
Author Information
Author(s): Ciarrocchi Alessia, D'Angelo Romina, Cordiglieri Chiara, Rispoli Ada, Santi Spartaco, Riccio Massimo, Carone Simona, Mancia Anna Laura, Paci Simone, Cipollini Elena, Ambrosetti Davide, Melli Marialuisa
Primary Institution: Department of Biology, Bologna University, Bologna, Italy
Hypothesis
Tollip is involved in the sumoylation process and interacts with sumoylation enzymes.
Conclusion
Tollip is shown to be involved in the sumoylation of proteins, including the IL-1 receptor.
Supporting Evidence
- Tollip interacts with sumoylation enzymes, suggesting its role in the sumoylation process.
- Tollip is shown to be sumoylated and may act as a ligase.
- The IL-1 receptor is identified as a sumoylation target of Tollip.
- Tollip's nuclear localization suggests a role in nuclear processes.
- Tollip's interaction with Daxx indicates a potential role in transcriptional regulation.
Takeaway
Tollip helps attach a special tag to proteins that can change how they work in the cell.
Methodology
The study used yeast two-hybrid screening and various cell transfection experiments to analyze Tollip's interactions and functions.
Digital Object Identifier (DOI)
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