PAI-1: An Integrator of Cell Signaling and Migration
2011
PAI-1: An Integrator of Cell Signaling and Migration
publication
Evidence: moderate
Author Information
Author(s): Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins
Primary Institution: Center for Cell Biology and Cancer Research, Albany Medical College
Hypothesis
The study investigates the role of PAI-1 in regulating cellular migration and signaling pathways.
Conclusion
PAI-1 plays a crucial role in coordinating cell migration through its interactions with various receptors and extracellular matrix components.
Supporting Evidence
- PAI-1 is a major determinant of the cellular migratory phenotype.
- High levels of PAI-1 correlate with poor prognosis in various cancers.
- PAI-1 interacts with multiple receptors to regulate cell migration.
Takeaway
PAI-1 helps cells move around by interacting with other proteins and the environment, which is important for healing and cancer progression.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website