Asthma and Frailty Risk
Author Information
Author(s): Ning Pingping, Mu Xin, Guo Xingzhi, Zhou Rong, Tian Ge, Li Rui
Primary Institution: Department of Geriatric Neurology, Shaanxi Provincial People’s Hospital
Hypothesis
Is there a causal relationship between asthma and the risk of frailty?
Conclusion
Asthma is causally associated with an elevated risk of frailty.
Supporting Evidence
- Genetic susceptibility to asthma was associated with an increased risk of frailty.
- The study utilized data from the UK Biobank and the FinnGen Consortium.
- Results were validated in two independent asthma datasets.
- The analysis included 67 SNPs as instrumental variables.
Takeaway
If you have asthma, you might be more likely to feel weak and tired as you get older.
Methodology
Two-sample Mendelian randomization analyses using genetic instruments were performed to assess the causal effect of asthma on frailty.
Potential Biases
Potential bias due to sample overlap in the discovery phase.
Limitations
The study's findings may not be generalizable to populations outside of European ancestry.
Participant Demographics
Participants were of European ancestry.
Statistical Information
P-Value
5.00E-28
Confidence Interval
1.075–1.109
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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