New Water-Based Topical Carrier for Drug Delivery
Author Information
Author(s): Silvander Mats, Ringstad Lovisa, Ghadially Ruby, Sköld Thomas
Primary Institution: YKI, Institute for Surface Chemistry
Hypothesis
Can a new water-based topical formulation improve drug penetration while minimizing skin barrier disturbance?
Conclusion
The new formulation showed superior delivery properties for both lipophilic and hydrophilic drugs compared to traditional references.
Supporting Evidence
- The new formulation outperformed vaseline and xanthan gum gel in delivering drugs to the skin.
- Hydrophilic and lipophilic drugs were effectively delivered using the new formulation.
- The formulation containing non-ionic adjuvants showed the best results for drug delivery.
Takeaway
Scientists created a new lotion that helps medicine get into the skin better without hurting it. It works well for both oily and watery medicines.
Methodology
The study used in vitro diffusion cells with pigskin to test the penetration of three variations of a lipid formulation.
Limitations
The study primarily focused on in vitro results, and in vivo effects will be addressed in future research.
Participant Demographics
Pigskin from 7-8 month old pigs was used for the in vitro tests.
Digital Object Identifier (DOI)
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