Thymoquinone's Antibacterial Effects Against Oral Pathogens
Author Information
Author(s): Kouidhi Bochra, Zmantar Tarek, Jrah Hanene, Souiden Yosra, Chaieb Kamel, Mahdouani Kacem, Bakhrouf Amina
Primary Institution: Faculty of Pharmacy, Monastir University
Hypothesis
Can thymoquinone enhance the effectiveness of antibiotics against oral bacteria?
Conclusion
Thymoquinone shows selective antibacterial activity against oral bacteria and may enhance the effectiveness of certain antibiotics.
Supporting Evidence
- Thymoquinone showed a selective antimicrobial property against several oral bacteria.
- Seven out of 16 oral strains were sensitive to thymoquinone.
- Thymoquinone reduced the MIC of tetracycline and benzalkonium chloride significantly.
- The study demonstrated thymoquinone's potential as a resistance-modifying agent.
Takeaway
Thymoquinone, a natural compound, can help fight bad bacteria in the mouth and make antibiotics work better.
Methodology
The study determined the minimum inhibitory concentrations (MICs) of thymoquinone and antibiotics using broth microdilution and efflux assays.
Limitations
Further clinical studies are needed to assess the practical applications of thymoquinone.
Participant Demographics
The strains were isolated from Tunisian children suffering from dental caries.
Digital Object Identifier (DOI)
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