Development and Notch Signaling Requirements of the Zebrafish Choroid Plexus
Author Information
Author(s): Bill Brent R., Balciunas Darius, McCarra Joshua A., Young Eric D., Xiong Toua, Spahn Ashley M., Garcia-Lecea Marta, Korzh Vladimir, Ekker Stephen C., Schimmenti Lisa A.
Primary Institution: University of Minnesota
Hypothesis
Notch signaling is required for the development of the zebrafish choroid plexus.
Conclusion
The study identifies the zebrafish choroid plexus and demonstrates a requirement for Notch signaling in its development.
Supporting Evidence
- This is the first description of the zebrafish choroid plexus.
- The study shows that Notch signaling is critical for the development of the choroid plexus.
- Three Notch signaling pathway members were identified as mediating the effects on choroid plexus development.
Takeaway
This study shows how a part of the brain called the choroid plexus forms in zebrafish and that a special signal called Notch is important for its development.
Methodology
The study used a transgenic zebrafish line to visualize choroid plexus development and pharmacological and genetic methods to assess the role of Notch signaling.
Statistical Information
P-Value
1.98*10−11
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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