Malaria in Children After Preventive Treatment
Author Information
Author(s): Konaté Amadou T., Yaro Jean Baptiste, Ouédraogo Amidou Z., Diarra Amidou, Gansané Adama, Soulama Issiaka, Kangoyé David T., Kaboré Youssouf, Ouédraogo Espérance, Ouédraogo Alphonse, Tiono Alfred B., Ouédraogo Issa N., Chandramohan Daniel, Cousens Simon, Milligan Paul J., Sirima Sodiomon B., Greenwood Brian M., Diallo Diadier A.
Primary Institution: Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso
Hypothesis
Does intermittent preventive treatment of malaria in children lead to increased incidence of malaria after the treatment ends?
Conclusion
IPT with SP+AQ was associated with a small increase in the incidence of clinical malaria in the subsequent malaria transmission season.
Supporting Evidence
- Children who received IPTc had a higher incidence rate of malaria episodes compared to those who received placebos.
- The incidence rate ratio for clinical malaria was 1.12, indicating a small increase in risk for children in the IPTc group.
- Children who received IPTc had a lower prevalence of malaria infection but higher parasite density if infected.
Takeaway
Giving kids medicine to prevent malaria might make them get malaria a little more after the medicine stops, but it helps them stay healthier while they are taking it.
Methodology
A randomized, double-blind, placebo-controlled trial comparing IPTc with placebos in children aged 3–59 months.
Limitations
The study only examined the effects of IPTc during one malaria transmission season.
Participant Demographics
Children aged 3–59 months from four villages in Burkina Faso.
Statistical Information
P-Value
0.003
Confidence Interval
95%CI; 3.67–4.02
Statistical Significance
p=0.003
Digital Object Identifier (DOI)
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