Neuroprotective Effects of Memantine, Hyperbaric Oxygen, and Brimonidine in Rat Retinas
Author Information
Author(s): Yiğit Ulviye, Erdenöz Serkan, Uslu Ünal, Oba Ersin, Cumbul Alev, Çağatay Halil, Aktaş Şamil, Eskicoğlu Emiray
Primary Institution: Bakırköy Dr. Sadi Konuk Training and Research Hospital Clinics of Eye Diseases, Istanbul, Turkey
Hypothesis
This study aims to compare the efficacy of memantine, hyperbaric oxygen therapy, and brimonidine in treating acute ischemia reperfusion injury in rat retinas.
Conclusion
Memantine, hyperbaric oxygen therapy, and brimonidine were effective in reducing damage from acute ischemia reperfusion in rat retinas.
Supporting Evidence
- Memantine treatment resulted in a retinal ganglion cell count of 215.89±8.36.
- HBO therapy resulted in a retinal ganglion cell count of 208.69±2.05.
- Brimonidine treatment resulted in a retinal ganglion cell count of 172.27±8.16.
- The apoptotic index was significantly lower in the treatment groups compared to the ARI group.
- Memantine and HBO therapy showed similar neuroprotective effects.
Takeaway
This study tested three treatments to help protect rat eyes from damage after a lack of blood flow, and found that all three treatments helped.
Methodology
Thirty adult Wistar albino rats were divided into five groups and subjected to acute retinal ischemia, followed by treatment with memantine, HBO therapy, or brimonidine, and then evaluated histologically.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Thirty adult Wistar albino rats, 24 weeks old.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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