Alginate Hydrogel for Long-Acting Drug Delivery of Aripiprazole
Author Information
Author(s): Nguyen Hy D., Jang Munsik, Ngo Hai V., Gil Myung-Chul, Jin Gang, Cui Jing-Hao, Cao Qing-Ri, Lee Beom-Jin, Lee Bae Hoon
Primary Institution: Ajou University
Hypothesis
Can the physicochemical properties and drug release of alginate hydrogel containing poorly water-soluble aripiprazole be optimized for long-acting injectable formulations?
Conclusion
The optimized alginate hydrogel formulation can achieve a clinically acceptable gelation time and sustained drug release for at least 14 days.
Supporting Evidence
- The alginate hydrogel was injectable using a small 23 G needle.
- The optimal formulation had a gelation time of 9.1 minutes.
- The hydrogel maintained muscle-mimicking stiffness of 3.55 kPa.
- Sustained drug release was observed over a two-week period.
Takeaway
This study created a special gel that can be injected and slowly releases medicine over time, helping patients take their medicine more easily.
Methodology
The study involved preparing alginate hydrogel formulations, testing their gelation time, injectability, swelling, degradation, and drug release profiles.
Limitations
The study primarily focused on in vitro conditions, which may not fully replicate in vivo behavior.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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