Effects of Hypericum triquetrifolium on Inflammation
Author Information
Author(s): Saad Bashar, AbouAtta Bernadette Soudah, Basha Walid, Hmade Alaa, Kmail Abdalsalam, Khasib Said, Said Omar
Primary Institution: Research and Development Regional Center—The Galilee Society
Hypothesis
This study aims to examine the anti-inflammatory mechanism of Hypericum triquetrifolium by measuring the expression and release of pro-inflammatory cytokines in human monocytic cells.
Conclusion
Hypericum triquetrifolium extracts inhibit the production of LPS-induced TNF-α and nitric oxide by downregulating their gene expressions.
Supporting Evidence
- Hypericum triquetrifolium extracts significantly suppressed the LPS-induced nitric oxide release.
- The extracts inhibited the transcription of iNOS and TNF-α in a dose-dependent manner.
- No significant effects were observed on the release of IL-6.
Takeaway
This study found that a plant called Hypericum triquetrifolium can help reduce inflammation in cells by lowering certain harmful substances.
Methodology
The study used THP-1 human monocytic cells treated with lipopolysaccharide and varying concentrations of Hypericum triquetrifolium extracts to measure levels of nitric oxide and pro-inflammatory cytokines.
Limitations
The study was conducted in vitro, which may not fully represent in vivo effects.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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